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Rebuilding the Temple of God, one stone at a time!
Bone & Joint Health
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Rebuilding the Temple of God, one stone at a time! | |||
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Bone & Joint Health |
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Complete
Bone
& Joint Health Package...
*Mycoplasma infections in Rheumatoid Arthritis patients
The History Of The Search For Cause And Cure In the 1930's, a bacterial cause for rheumatoid arthritis was investigated but the research was short-lived except for distinct cases of acute infectious or septic arthritis. In 1939, the first real lead regarding an infectious cause for rheumatoid arthritis arose when mycoplasma, an atypical viral-like bacteria, was isolated from the exudate and tissue of rheumatic patients. Investigators had already shown that mycoplasmas cause arthritis in mice, rats, chickens, goats, and cows. They had found mycoplasmas in the genitourinary tracts of humans too, especially females. In 1949 at the International Congress on Rheumatic Diseases the possible relationship between mycoplasmas and joint disease was reported. After obtaining one of the first National Institutes of Health (NIH) research grants in 1950, Thomas McPherson Brown, M.D. and colleagues at the arthritis research unit reported the following year that the rheumatoid disease mechanism was more of an immunologic reaction of antigen and antibody (with mycoplasma as the suspected antigen) rather than the infectious and transmissible type. In 1955, the research unit reported that mycoplasmas, unlike bacteria and viruses could live in tissue cell cultures without destroying the tissue cells. To further support mycoplasmas as a causative agent/antigen, in 1964 a high incidence of mycoplasma antibodies in the blood of rheumatoid arthritis patients and lupus patients was found, indicating current or previous infection. Also recognized was a 4:1 higher incidence of mycoplasma antibodies in females suggesting a correlation with the higher incidences of rheumatoid arthritis in females. Effect
of MALP-2, a lipopeptide from Mycoplasma fermentans, on bone
resorption in vitro. Mycoplasma
arthritis in man and mechanisms of its pathogenesis]
Why Arthritis?" Throughout the years, the theories that focus on mycoplasma as the responsible infectious agent and on tetracycline as the antibiotic treatment of choice have been hampered by lack of adequate funding for more research and from politics. "Why Arthritis?" by Harold W. Clark, Ph.D., one of Brown's colleagues, assesses the rheumatoid diseases, decades of research, the search for a cure, and the frustration of researchers whose case for anti-mycoplasma therapy was overlooked for 40 years by the government and various arthritis organizations. Clark believes efforts were impeded because a safe, simple treatment threatens the medical establishment since patients would then require less medical intervention. Many physicians remain skeptical and still do not suggest antibiotic treatment to their patients. The Arthritis Foundation was seemingly unimpressed even after antibiotic therapy was deemed as safe and effective Leaky-Gut Syndrome May Play A Role In ArthritisSome researchers claim that leaky-gut syndrome, or increased intestinal permeability, is implicated in dozens of diseases. The syndrome is the result of the wall of the small intestine being damaged. A healthy intestine allows only nutrients to pass into the bloodstream. When the intestine is damaged, larger molecules such as incompletely digested fats, proteins, starches, and even bacteria, also permeate the intestinal wall. The larger molecules, recognized by the body as foreign substances, can trigger an immune response in other organs. Some researchers claim that healing a leaky gut with strict diet and nutritional supplements can help control conditions such as insomnia, obesity, bad breath, as well as a wide range of diseases including asthma, eczema, and arthritis. Many researchers agree that the intestinal tract is a key player in the immune system, but whether or not the gut is the root of so many problems is still the subject of hot debate. The small intestine is a convoluted, 25-foot tube between the stomach and the large intestine. Its lining is comprised of millions of villi, or leaflike structures, which in turn are covered with millions of microvilli. The villi and microvilli harbor bacteria and yeast, which normally maintain a healthy balance and help to carry out the main function of the intestine which is to break down food into nutrients which the body can use, and to move along waste and harmful substances to the bowel. Most of the potentially dangerous material a human encounters is in food, therefore the gut's immune function is crucial. Researchers now estimate that more than two thirds of all immune activity occurs in the gut. In some people the wall of the gut seems to have been breached. Researchers are unsure how these microscopic breaches occur but possible causes include food allergies, excessive amounts of aspirin or ibuprofen, certain antibiotics, excessive drinking, a compromised immune system, or a parasitic infection. Leaky-gut syndrome is not a disease itself but is thought to play a role in other diseases. Allowing undigested food or bacteria into the bloodstream causes the immune system to react. As this occurs the body reacts in a number of ways such as rash, diarrhea, migraines, joint pain, and even psychological symptoms. These problems can add up to a disorder which has no obvious relation to the original cause. Until a few decades ago, the theory was that unless a medical problem directly affected the gut, it worked normally. Now physicians know that trauma to other parts of the body causes the gut to react. One researcher, Leo Galland M.D., estimates that the syndrome plays a role in 70 percent of people with chronic fatigue syndrome, eight out of 10 aspirin or ibuprofen users, most alcoholics, and anyone who is hospitalized. Galland also believes that parasites that can lead to leaky-gut syndrome lurk in most municipal water systems. One common prescription for leaky-gut syndrome is an elimination diet. A series of urine and blood tests is used to assess food allergies. Based on the results of the tests, whole categories of food such as dairy products or wheat products, are eliminated and added back over time as the patient is monitored for reactions. Strict elimination diets should be used only under close medical supervision, otherwise malnutrition can result. The nutritional mainstay, fiber, may also play a role in healing problems of the gut. A National Institute of Health funded study from Louisiana State University indicated that rats who ate no fiber had abnormal intestinal linings. Other research shows that glutamine, a nonessential amino acid, also plays a role in maintaining the integrity of the intestinal wall. To conclude from available research that leaky-gut syndrome is widespread, treatable, and the cause of all sorts of problems is a jump scientists and most doctors are unwilling to make. The gut and glutamine are definitely hot areas of current and ongoing research. It is recognized though that care and maintenance of the gut makes sense in any case. REFERENCE: |
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