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Studies on Beta Sitosterol and the Prostate

There are many classic double blind studies done with real People on the effects of beta-sitosterol on benign prostate hypertrophy or BPH. We have summarized some of these studies .Aall of which indicate that beta-sitosterol is a highly effective for BPH.

One of the very best and most recent studies done was published in the British Journal of Urology, volume 80 (1997), at the University of Dresden. Drs. Klippel, Hilti and Schipp studied 177 men for 6 months who suffered from BPH. Half the men got a placebo and half got the prescription extract Azuprostat containing 130mg of beta-sitosterol. They cited a full 32 references to substantiate their research. They carefully screened all the men and tested them extensively during the study. They concluded, "These results show that beta-sitosterol is an effective option in the treatment of BPH.

"A very unique review of 31 years of studies was published in the volume 280 of the Journal of the American Medical Association (1998) where they chose 18 different trials involving 2,939 men in total who were treated for BPH with strong extracts of saw palmetto containing beta-sitosterol. They said after reviewing all these studies, "The evidence suggests that Serenoa repens (saw palmetto) improves urologic symptoms and and flow measures."

Another unique study in a different manner was done by Dr. Buck in the British Journal of Urology, volume 78 (1996). At the Department of Urology in Glasgow, Scotland he did a 12 page review of herbal therapy for the prostate including Harzol, Tadenan, Permixon, Strogen and Sabalux (all European prescription herbal extracts standardized for beta-sitosterol content). He documents his review with 59 published worldwide studies and discusses the biological basis of prostate illness. His conclusions of the efficacy of herbal treatment of prescription drugs and therapy are well founded certainly.

In the Lancet, vol 345 (1995) a very professional study was done at the University of Bochum in Herne, Germany by Dr. Berges and his associates. They used pure beta-sitosterol with 200 men half of whom received a placebo over the course of a year. They said, "Significant improvement in symptoms and urinary flow parameters show the effectiveness of beta-sitosterol in the treatment of BPH." This is clearly one of the most important and well done studies on prostate ever published.

In volume 55 of Current Therapeutic Research (1994) a study done at the University of Brussels, Belgium by Dr. Braeckman using Prostaserene (an extract standardized for beta-sitosterol) for a mere six weeks led him to conclude, "Traditional parameters for quantifying prostatism, such as the International Prostate Symptom Score, the quality of life score, urinary flow rates, residual urinary volume, and prostate size were found to be significantly improved after only 45 days of treatment. After 90 days of treatment, a majority of patients (88%) and treating physicians (88%) considered the therapy effective."

A study published in volume 21 of European Urology (1992), at the Institute of Clinical Medicine at the University of Rome, DiSilverio and his colleagues studied 35 men with BPH for 3 months and gave half of them a placebo (inert capsules). They concluded, "On the basis of these considerations, monotherapy with S. repens extract (beta-sitosterol extracted from saw palmetto) may be more favorably accepted, since on account of similar clinical results, when compared to the combination therapy cyproterone acetate plus tamoxifen..."

In the German journal Wiener Klinische Wochenschrift, volume 22 (1990) at eight different urological clinics in Europe 263 total patients with BPH were studied over a two month period. They were given either Tadenan (a Pygeum africanum extract standardized for beta-sitosterol content) or a placebo. This very extensive study compiled from different clinics and different doctors yet all agreed that, "Treatment with the Pygeum africanum extract led to a marked clinical improvement: a comparison of the quantitative parameters showed a significant difference between the Pygeum africanum group and the placebo group with respect to therapeutic response."

Again, in Minerva Urologica e Nefrologica, volume 39 (1987), Drs. Bassi et al at the University of Padova studied 40 men with BPH with and extract of Pygeum africanum with a high beta-sitosterol content. Half the men received a placebo and many parameters were measured for the two month study. They concluded, "The preliminary results demonstrate a significant improvement of the frequency, urgency, dysuria (difficult, painful urination) and urinary flow in patients treated with the active drug."

In the Italian journal Minerva Urologica e Nefrologica, volume 37 (1985), doctors at the University of Padova studied the effect of beta-sitosterol extract on 27 men with BPH. Dr. Tasca and his associates measured urine flow and other parameters in men ranging from ages 49 to 81 compared to men receiving a placebo.

In the journal Urolage A, volume 24 (1985) at the University of Basel, Switzerland, Dr. Vontobel and his colleagues studied a strong extract of nettles containing a high concentration of beta-sitosterol in a double blind study of 50 men for nine weeks. They said that the use of beta-sitosterols from nettles, "The evaluation of the objective parameters showed significant differences."

The British Journal of Clinical Pharmacology in volume 18 (1984) at the Hospital Ambroise in Paris, Champault and two other doctors did a classic double blind study with 110 men half of them getting a placebo. They concluded, "Thus as predicted by pharmacological and biochemical studies PA109 (4 tablets of Permixon daily) would therefore appear to be a useful therapeutic tool in the treatment of BPH."

In Medical Science Research, volume 16 (1983), Drs. Malini and Vanithakumari at the Institute of Medical Sciences in Madras, India studied the effect of beta-sitosterol on the fructose concentration of the prostate. Fructose is vital to the function of the prostate with regard to the androgenic hormones such as DHEA and testosterone. This was a very unique and thorough study lasting almost two months.

In volume 77 of the German journal Midizinische Klinik (1982) a study done at the Urological Clinik of Krankenhauser in Ludenscheid-Hellersen was performed on 23 patients. Dr. Szutrely gave the patients either Harzol (herbal extract standardized for beta-sitosterol content) or a placebo for patients with prostate enlargement over a two month period. They measured their prostates with ultrasound equipment before and after treatment. At the end he said, "Within the scope of a controlled double blind study to demonstrate the effect of conservative therapy of benign prostatic hyperplasia with Harzol, ultrasonic examination of the prostate adenoma (enlargement) was carried out on 23 patients before and after therapy with the trial preparation of a placebo. Within a two month treatment with Harzol there was a significant change in echo structure of the prostate adenoma, and this is interpreted as a reduction in the interstitial formation of oedema (swelling)."

Studies on Beta Sitosterol and Cholesterol

If there was only one supplement you could take to reduce your cholesterol it should be beta-sitosterol taken in 300-600 mg doses every day. Beta-sitosterol is the most studied, most proven, most effective suplement to lower total and LDL cholesterol. The studies on this in the medical journals actually go back 50 years yet most people have never even heard of it

Upjohn Pharmaceuticals tried to make a prescription analog (chemical relative) of it decades ago for lowering cholesterol but did not succeed - the natural molecule works best. The scientific community has been well aware of it and clinics around the world have done extensive studies on both humans and animals including gall bladder, bile and liver functions since these are all part of the cholesterol metabolism. The major mechanism this seems to be effective is simply by preventing the dietary cholesterol from being absorbed in the intestines where fat is digested. Another way this seems to work is by increasing the flow of bile acids, which binds the cholesterol in the digestive track and excretes it in the feces.

At McGill University in Montreal (Can. J. Physiol. Pharmacol. 75, 1997, p. 217-27) doctors did a review of the literature on beta-sitosterol and cholesterol metabolism. They researched in detail 18 major studies that used sitosterols to lower cholesterol and triglycerides. They concluded, "addition to diet of phytosterols represents an effective means of improving circulating lipid profiles to reduce risk of coronary heart disease." This study came complete with forty high quality references and left no doubt about the effectiveness of phytosterols on humans. Also at McGill University (Metabolism Clinic Experiments 47, 1998, p. 751-6) patients on a fixed diet were given sterols from pine oil for a mere ten days in a strict, randomized crossover study. This was not a low fat or low cholesterol diet at all. They successfully lowered both their total cholesterol and LDL levels in this short term placebo controlled experiment. They concluded, these results demonstrate the short term efficacy of pine oil plant sterols as cholesterol lowering agents"

A very interesting study was done at the Center for Human Nutrition in France (Ann. Nutr. Metab. 39, 1995, p. 291-5) in that healthy people with normal cholesterol levels were given beta- sitosterol to see if their normal levels could be lowered even further. We always think of studies as using unhealthy people with pathological cholesterol levels given supplements to make them normal again. Amazingly enough the healthy people lowered their normal cholesterol levels even more with no change in diet or exercise. In fact, they were a full 10% lower in only a month. This kind of effect is really fascinating. They said, "The present results may be of great interest in the prevention of high cholesterol diet-associated risks, especially in the prevention of cardiovascular diseases. Since beta-sitosterol was so effective for people who didn't even need it, think what it will do for those people who do need to lower their blood lipids. They concluded, "These findings suggest that a significant lowering of plasma total and LDL cholesterol can be effected by a modest dietary intake of soybean phytosterols"

A good study was done at the Wageningen Agricultural Institute in the Netherlands, the same clinic that did so much good research on trans fatty acids (Am. J. Clin. Nutr. 72, 2000, p. 1510-5). They gave men and women a margarine containing plant sterols and got very significant reductions in cholesterol as well as lower LDL levels in only three weeks. Why a clinic would give margarine to people after studying the negative effects of hydrogenated oils is another matter. Again, these were healthy subjects with normal cholesterol levels, yet they still got great benefits very quickly with no change in diet or exercise.

At Uppsala University in Sweden (Eur. Heart J. Supp. 1, 1999, p. S80-S90) the doctors wanted to give the volunteers the phytosterols in conjunction with a cholesterol lowering diet to see the results of a more comprehensive lifestyle program. The results were really impressive in that the men and women lowered total cholesterol a full 15% and LDL cholesterol a full 19% in less than a month. The shows the very dramatic results you can get with just adding some reasonable dietary changes even without any exercise program at all.

At the University of British Columbia at their St. Paul's Hospital (American Journal of Medicine 107 (1999) p. 588-94) a very impressive review was done complete with 86 references of using plant sterols to lower total cholesterol and LDL. They said of the recent research, " In 16 recently published human studies that used phytosterols to decrease plasma cholesterol levels in a total of 590 subjects, phytosterol therapy was accompanied by an average 10% decrease in total cholesterol and 13% decrease in LDL cholesterol levels." This is the best review to date and should convince anyone of the effectiveness of sterols over drugs.

At the University of Kagawa in Tokyo two studies were done. The first was done on healthy young men who were given plant sterols for only five days. In this short time their cholesterol levels fell measurably (Joshi Eiyo Daigaku Kiyo 14, 1983, p. 165-72). The second study was done on healthy young women (same journal 15, 1984 p. 11-18) again giving them plant sterols for only five days. "Administration of phytosterol (mainly sitosterol) increased the output of fecal cholesterol." These were all healthy young Japanese people eating a traditional low-fat diet who did not have a cholesterol problem to begin with, yet they received measurable results in only five days.

At the University of California in San Diego men were isolated in a hospital ward and fed 350 mg of cholesterol and then beta-sitosterol supplements (American Journal of Clinical Nutrition 35, 1982, p. 697-700). This resulted in a 42% decrease in cholesterol absorption in the intestines. They said, "Evidently, the judicious addition of beta-sitosterol to meals containing cholesterol rich foods will result in a decrease in cholesterol absorption with a consequent decrease in plasma cholesterol"

The University of Helsinki took a big interest in lowering cholesterol with plant sterol therapy back in 1988. The first study (Clinical Chimica Acta 178, p. 41-9) studied familial (genetic) hypercholesteremia. The higher the sterol levels they found in the patients blood the more cholesterol was excreted rather than absorbed. The second study was in 1989 (Metabolism Clinical Experiments 38, p. 136-40). Men were studied again for blood levels of sterols and they found the higher the levels the more cholesterol was excreted successfully. The third study in 1994 (American Journal of Clinical Nutrition 59, p. 1338-46) studied vegetarians who eat twice as many plant sterols as normal people. They showed one reason vegetarians have lower cholesterol levels besides the food they eat is the efficiency of their cholesterol excretion due to their intakes of plant sterols. In the last study in 1999 (Current Opinion Lipidology 10, p. 9-14) they said, "Plant sterols may be useful for the treatment of hyper-cholesteremiaãƒ•hey may have a potent cholesterol lowering effect as shown in normal and hypercholesteremic men and women with and without coronary heart disease and diabetes mellitus"

The best study of all was a review from the University of British Columbia (American Journal of Medicine 107, 1999, p. 588-94). This included a full 86 references, and went over seventeen different human studies using plant sterols to lower cholesterol since 1951 (Proceedings of the Society for Biological Medicine 78, 1951, p. 143-7). A total of 590 men and women were used in these studies with phytosterol therapy resulting in an average 10% reduction in total cholesterol and a 13% reduction in LDL cholesterol. They found this worked best in high-fat diets; the worse the diet the more results the researchers got.

Prostate Cancer Links

Natural Prostate health Links

Allopathic Links

www.feminist.org/other/bc/sloanarticle.html Here are some of the firms who profit from selling cancer-causing chemicals AND cancer treatment drugs.

www.fightingcancer.com Jonathan Chamberlain, the author of Fighting Cancer: A Survival Guide, has posted his entire book online for free public reading.

www.fuelmiser.com Fuel costs are cut 10-20% and emissions are cut by up to 90%. FUELMiser is a small magnetic device that is quick and easy to install and is permanent. Fuel emissions reduced mean less air pollution and less disease. By some estimates, 30% - 40% of cancer is caused by petrochemicals.

www.getenergized.com Energetic exercise site.

www.gerson.org Gerson Institute, Tijuana, Mexico.

www.geocities.com/graviolaforcancer Graviola - natural cancer cure from the Amazon.

https://grc.com/x/ne.dll?bh0bkyd2 How vulnerable is your computer while you are using the Internet? Test your firewall here.

www.greenpower.com Greenpower juicers are economical and effective.

www.gyncancers.about.com/ Information about gynecologic cancers. Lots of links.

www.healthgenesis.com A source of apricot seeds.

www.healthy.net This is the MOST VISITED natural health site on the Internet.

www.healthy.net/asp/templates/article.asp?PageType=Article&ID=993 Learn about your lymph system.

www.healthy.net/asp/templates/book.asp?PageType=Book&ID=182 The story of Essiac.

www.healthy.net/pan/pa/homeopathic/natcenhom/index.html National Center for Homeopathy

www.healthy.net/pan/pa/naturaltherapies/apma/index.html American Preventive Medical Association. Health care practitioners who use nutritional and other complementary therapies.

www.homeopathy.org North American Society of Homeopaths (NASH)

www.hoxsey.com Information on Hoxsey Therapy, Bio-Medical Center, Tijuana, Mexico. Harry Hoxsey was the first American medical practitioner to set up shop in Mexico. He had been harassed for decades by the AMA and the FDA. The NCI refused to investigate Hoxsey's herbal formulas. All of the herbs used by Hoxsey have since been shown to have anti-cancer, anti-tumor, and anti-microbial properties in controlled laboratory experiments. Hoxsey claimed a 25% cure rate for terminal cases after surgery, radiation and chemotherapy had failed, and an 80% cure rate for people who had not received prior treatments from M.D.'s.

www.humlegaarden.dk Humlegaarden Clinic, Denmark.

www.iatclinic.com Immuno-Augmentation Therapy (IAT), Dr. Lawrence Burton, Bahamas. Two satellite clinics have been established in Dusseldorf, Germany and Playas, Tijuana, Mexico.

www.ibiblio.org/farming-connection/index.html Information on sustainable farming. This must become the future of agriculture if we are to get rid of cancer-causing toxic chemicals in our food.

www.ineways.com Neways is endorsed by leading cancer doctors because their products contain no carcinogens. Neways offers 15 product lines including cosmetics, personal care products, household products, and much more.

www.infraredsauna.net Since the sauna is the safest, most efficacious and economical way of removing toxic chemicals from the body, this makes it a household necessity. Mention Alkalize For Health and receive a $100 discount on your sauna.

www.iptq.org Insulin Potentiation Therapy increases the sensitivity of cancer cells to chemotherapy drugs, so a far smaller quantity of chemotherapy drugs are needed. The result is little, if any, toxicity.

www.kalamark.com/devices Supplier of the Rife machines.

www.kathykeeton-cancer.com Hydrazine sulphate.

www.kemsa.com Kem, S.A. Laboratories - source of vitamin B17.

www.lancasterhealth.com/ Maharishi Ayur-Veda Medical Center, Lancaster, Massachusetts Recognized as one of the 10 Best Health Spas in the World --Harpers & Queen

www.learn2.com/08/0849/0849.asp Learn to grow sprouts. Online tutorial.

www.lef.org Life Extension Foundation.

www.lef.org/magazine/mag99/may99-cover.html Tamoxifen causes cancer.

www.lifeforce-intl.com Source of Body Balance and OsteoProCare nutritional supplements.

www.living-foods.com This site has an extensive selection of links relating to diet.

www.livingstonmedcentr.com Livingston Foundation Medical Center, San Diego.

www.lupronvictims.com Site for people damaged by the chemo drug called Lupron.

www.maharishitm.org/tmlinks.htm Links to TM-related Internet sites around the world, courtesy of the TM Program in Lebanon.

www.marineminerals.com Source of Liquid Ionic Trace Minerals, economical and absorbable by the body.

www.medical-library.net network of over 225 integrated web sites. One of the most interesting and comprehensive sources of medical information. This site can help you locate an alternative minded physician near where you live.

www.members.tripod.com/~hoxsey Bio-Medical Center, Tijuana, Mexico offering Hoxsey Therapy.

www.members.tripod.com/~pain-man/index.html 650 page site on the subject of chronic pain.

www.mercola.com Dr. Mercola's Optimal Wellness Center - 15,000 pages on the subject of natural medicine! This is the second most visited natural health site on the Internet.

www.mercola.com/article/cancer/cancer_options.htm Only a few rare cancers comprising 2% - 4% of all cancer cases in the US respond favorably to chemotherapy. Find out which cancers these are at this web page.

www.midstateag.com Farm For Profit - helping farmers move away from chemical dependence. Not organic, but in the right direction.

www.millennium-debate.org/indsun11july.htm More than 350 pollutants found in British breast milk.

www.mum.edu/tm_research/mav/welcome.html Bibliography of research on Maharishi Ayurveda.

www.mum.edu/tm_research/tm_biblio/welcome.html Bibliography of research on Transcendental Meditation and the TM-Sidhi Program.

www.mwt.net/~drbrewer/highpH.htm Dr. Brewer's paper on high pH cancer therapy using alkaline mineral salts of cesium, rubidium and potassium.

Caution: For any suspected or known illness or dysfunction, always consult your physician for medical diagnosis and treatment first. Statements contained herein have not been evaluated by the Food and Drug Administration. Products mentioned herein are not intended to diagnose, treat, cure any disease and statements made are for education purposes and are not intended to replace the advice of your family doctor. Rainbow does not dispense medical advice, prescribe, or diagnose illness.

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